The story of the 1925 Nome, Alaska, diphtheria epidemic describes the plight of the patients, with a blizzard imminent and the much-needed serum seven hundred miles away, as teams of sled dogs and their drivers become the only hope for survival.

Gold, men, and dogs -- Outbreak -- Quarantine -- Gone to the dogs -- Flying machines -- Hunters of the North -- Rule of the 40's -- The real heroes were dogs -- Red tape -- The ice factory -- Up against it good and strong -- Saved.